Serious - Use Alternative (2)ribociclib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)trifluoperazine and doxepin both increase QTc interval. anticholinergic/sedative combos and doxepin both decrease cholinergic effects/transmission. Migraines: Are they triggered by weather changes? commonly, these are "non-preferred" brand drugs or specialty Use Caution/Monitor. gabapentin enacarbil, doxepin. Contraindicated (1)tranylcypromine and doxepin both increase serotonin levels. Use Caution/Monitor.prochlorperazine and doxepin both increase sedation. Doxepin belongs to a class of drugs known as tricyclic antidepressants. Closely monitor for evidence of seizures when using higher dose of magnesium sulfate together with drugs that lower the seizure threshold. Always ask your health care professional for complete information about this product and your specific health needs. Modify Therapy/Monitor Closely. Minor/Significance Unknown. This tool may not cover all possible drug interactions. Serious - Use Alternative (1)selegiline transdermal and doxepin both increase serotonin levels. Either increases toxicity of the other by serotonin levels. Monitor Closely (1)clemastine and doxepin both increase sedation. Mechanism: unspecified interaction mechanism. Modify Therapy/Monitor Closely. Avoid taking selinexor with other medications that may cause dizziness or confusion. Other (see comment). Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Minor/Significance Unknown. Monitor Closely (1)doxepin and eribulin both increase QTc interval. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Modify Therapy/Monitor Closely. doxepin increases toxicity of amifampridine by Other (see comment). Risk of arrhythmias or hypotension. Avoid or Use Alternate Drug. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Sedatives are not technically considered antidepressants. Minor/Significance Unknown. Monitor Closely (1)doxepin increases and terbutaline decreases sedation. doxepin and clofazimine both increase QTc interval. Tricyclic antidepressants. Use Caution/Monitor. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Use combination with caution. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Developing drugs is a complicated process, because no two people . doxepin and levofloxacin both increase QTc interval. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. So avoiding it may be advised. Monitor Closely (2)doxepin and eliglustat both increase QTc interval. doxepin and dasatinib both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. secobarbital and doxepin both increase sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. orphenadrine and doxepin both increase sedation. Additive anticholinergic effects. Monitor Closely (2)thiothixene and doxepin both increase sedation. selinexor, doxepin. Either increases toxicity of the other by sedation. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. Always consult your healthcare provider before making changes to your medications or dosage. Effect of interaction is not clear, use caution. cyclizine and doxepin both increase sedation. Assess need to reduce dose of CYP2D6-metabolized drug. Avoid or Use Alternate Drug. Minor/Significance Unknown. doxepin increases and phentermine decreases sedation. Use Caution/Monitor. Avoid or Use Alternate Drug.doxepin and haloperidol both increase QTc interval. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor.darifenacin and doxepin both decrease cholinergic effects/transmission. Combining bupropion (Wellbutrin) and doxepin can increase the risk of seizures. Epub 2012 Jun 15. Other (see comment). Use Caution/Monitor. Avoid or Use Alternate Drug. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmias. Severe CNS toxicity associated with hyperpyrexia has been reported with the combined treatment of an antidepressant and rasagiline. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. Use Caution/Monitor. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Use lowest dose possible and monitor for respiratory depression and sedation. Monitor closely for signs of respiratory depression and sedation. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect. carbamazepine decreases levels of doxepin by increasing metabolism. Use Caution/Monitor. Accessed Aug. 19, 2019. Which antidepressant is best for you depends on a number of issues, such as your symptoms and any other health conditions you may have. Selected from data included with permission and copyrighted by First Databank, Inc. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Monitor Closely (2)doxepin increases effects of norepinephrine by unknown mechanism. Minor/Significance Unknown. Monitor Closely (1)doxepin and azithromycin both increase QTc interval. If either of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. ECGs should be obtained for high risk patients. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin increases and methamphetamine decreases sedation. Use Caution/Monitor. Modify Therapy/Monitor Closely. Tricyclic and tetracyclic drugs: Pharmacology, administration, and side effects. esketamine intranasal, doxepin. doxepin and pasireotide both increase QTc interval. In certain cases, they relieve depression . Use Caution/Monitor. doxepin oral brand names and other generic formulations include: bupropion hcl oral will increase the level or effect of doxepin oral by altering drug metabolism. If interruption not possible, patients requiring therapy with a drug that prolongs QT should be closely monitored. Cyclic antidepressants block the reabsorption (reuptake) of the neurotransmitters serotonin (ser-o-TOE-nin) and norepinephrine (nor-ep-ih-NEF-rin), increasing the levels of these two neurotransmitters in the brain. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin increases and phendimetrazine decreases sedation. Serious - Use Alternative (1)netupitant/palonosetron, doxepin. doxepin and thiothixene both increase QTc interval. mitotane decreases levels of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. almotriptan and doxepin both increase serotonin levels. J Clin Psychiatry. Use Caution/Monitor. doxepin increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Contraindicated. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. homatropine and doxepin both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. A Mayo Clinic expert explains. ECG monitoring is recommended. Use Caution/Monitor. Use Caution/Monitor. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Use Caution/Monitor. Monitor Closely (1)pregabalin, doxepin. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. ipratropium and doxepin both decrease cholinergic effects/transmission. ketamine and doxepin both increase sedation. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Monitor Closely (1)lormetazepam and doxepin both increase sedation. Copyright 2022 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Effect of interaction is not clear, use caution. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. Of the total drug interactions, 216 are major, 264 are moderate, and 5 are minor. givosiran will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. When oxymetazoline is combined with intranasal tetracaine for dental anesthesia, avoid or use alternant anesthetic in patients taking TCAs. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. olanzapine and doxepin both increase sedation. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Monitor Closely (1)chloral hydrate and doxepin both increase sedation. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Pamelor (prescribing information). Mechanism: unspecified interaction mechanism. Contraindicated.Monitor Closely (1)pimozide and doxepin both increase sedation. Monitor Closely (1)doxepin, phenylephrine ophthalmic. Avoid or Use Alternate Drug. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Use Caution/Monitor. A double-blind comparison of bupropion and amitriptyline in depressed inpatients. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling. Use Caution/Monitor. doxepin and iloperidone both increase QTc interval. Use Caution/Monitor.doxepin and salmeterol both increase QTc interval. oxybutynin transdermal and doxepin both decrease cholinergic effects/transmission. Additive CNS depression. doxepin, vilazodone. Avoid or Use Alternate Drug. doxepin and motherwort both increase sedation. doxepin, metaproterenol. JOHN'S WORT, TRICYCLIC COMPOUNDS/AMPRENAVIR; FOSAMPRENAVIR, LOWER STRENGTH TRICYCLICS; TRAZODONE/FLUOXETINE; PAROXETINE, SELECTED TRICYCLIC COMPOUNDS/SERTRALINE (>50 MG), SELECTED TRICYCLIC COMPOUNDS/DESVENLAFAXINE; VENLAFAXINE, AGENTS WITH HYPONATREMIA RISK/DESMOPRESSIN, SLT TRICYCLIC COMP; TRAZODONE/SERTRALINE (<= 50 MG), AGENTS WITH HYPONATREMIA RISK/DESMOPRESSIN (NOCTURIA), TRICYCLIC COMPOUNDS/INHALED MIXED-ACTING SYMPATHOMIMETICS, TRICYCLIC COMPOUNDS/INHALED DIRECT-ACTING SYMPATHOMIMETICS, TRICYCLIC COMPOUNDS/INHALED INDIRECT-ACTING SYMPATHOMIMETICS, SELECTED TRICYCLIC COMPOUNDS/DULOXETINE; FLUVOXAMINE, TRICYCLIC COMPOUNDS; MIRTAZAPINE/CLONIDINE, Understanding the Different Types of Depression, List Doxepin HCL side effects by likelihood and severity. Significant interaction possible (monitoring by your doctor required). 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). desflurane and doxepin both increase QTc interval. Monitor Closely (2)aripiprazole and doxepin both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)doxepin, methylphenidate. Contraindicated.Serious - Use Alternative (1)quinidine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. . Monitor Closely (1)butabarbital and doxepin both increase sedation. Use Caution/Monitor. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. isoproterenol, doxepin. Monitor Closely (1)doxepin and pazopanib both increase QTc interval. Additive anticholinergic effects. Moderately clinically significant. If it is already the next day, take your next dose at the regular time that night at bedtime. doxepin, dobutamine. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. doxepin and erythromycin stearate both increase QTc interval. Monitor Closely (1)doxepin and isoniazid both increase serotonin levels. Minor (1)doxepin increases effects of insulin glulisine by pharmacodynamic synergism. Monitor Closely (1)doxepin and romidepsin both increase QTc interval. Monitor Closely (1)valbenazine and doxepin both increase QTc interval. Minor/Significance Unknown. What is depression? Modify Therapy/Monitor Closely. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Monitor Closely (1)doxepin increases and modafinil decreases sedation. Additive anticholinergic effects.doxepin, trifluoperazine. QTc prolongation reported with higher than recommended doses of fostemsavir. Monitor Closely (2)diphenhydramine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.doxepin and levalbuterol both increase QTc interval. It can help prevent suicidal thoughts/attempts and provide other important benefits. Monitor Closely (1)secobarbital and doxepin both increase sedation. A list of the serotonergic psychiatric medications that can interact with linezolid can be found . doxepin and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Serious - Use Alternative (1)palonosetron, doxepin. Minor (1)doxepin and eucalyptus both increase sedation. Comment: When patients are administered peginterferon alpha-2b with CYP2D6 substrates, the therapeutic effect of these drugs may be altered. All rights reserved. Mechanism: unspecified interaction mechanism. If methylene blue must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Other (see comment). Serious - Use Alternative (1)doxepin and panobinostat both increase QTc interval. Monitor Closely (1)loprazolam and doxepin both increase sedation. Minor/Significance Unknown. health information, we will treat all of that information as protected health Monitor Closely (2)doxepin and albuterol both increase QTc interval. Monitor Closely (1)flavoxate and doxepin both decrease cholinergic effects/transmission. Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Monitor Closely (1)doxepin and epinephrine inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. It is in the tricyclic antidepressant class of medications. Use Caution/Monitor. Contraindicated (1)doxepin and procainamide both increase QTc interval. Use Caution/Monitor. Monitor Closely (1)lorazepam and doxepin both increase sedation. doxepin and orphenadrine both decrease cholinergic effects/transmission. Lefamulin is contraindicated with CYP3A substrates know to prolong the QT interval. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Contraindicated (1)doxepin and sotalol both increase QTc interval. privacy practices. hydrocodone, doxepin. Use Caution/Monitor. Avoid or Use Alternate Drug. Either increases effects of the other by pharmacodynamic synergism. cenobamate will decrease the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. In such cases, use is not recommended, or usage will have to be adjusted to prevent or reduce the risk of negative interactions occurring from other drugs, medical conditions, or even food and drink. Monitor Closely (1)levorphanol and doxepin both increase sedation. paliperidone and doxepin both increase sedation. Use Caution/Monitor. Use Caution/Monitor. doxepin and alfuzosin both increase QTc interval. Do not take more than 6 milligrams per day.Use this medication regularly to get the most benefit from it. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. butorphanol and doxepin both increase sedation. Avoid or Use Alternate Drug. This is a decision you and your doctor will make. Modify Therapy/Monitor Closely. Discontinue buprenorphine if serotonin syndrome is suspected. Avoid combinations; the risk of the interaction outweighs the benefit. Avoid or Use Alternate Drug. Stiripentol is a CYP3A4 inhibitor and inducer. Serious - Use Alternative (1)doxepin will decrease the level or effect of iobenguane I 131 by Other (see comment). Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride increases effects of doxepin by unknown mechanism. doxepin, vandetanib. Avoid or Use Alternate Drug. Monitor Closely (2)doxepin and trimipramine both decrease cholinergic effects/transmission. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor Closely (1)methylphenidate transdermal will increase the level or effect of doxepin by decreasing elimination. Effect of interaction is not clear, use caution. doxepin and sorafenib both increase QTc interval. Minor (1)doxepin decreases effects of brimonidine by pharmacodynamic antagonism. This medication is used to relieve itching from certain skin conditions (such as atopic dermatitis, eczema, neurodermatitis). Use Caution/Monitor.Serious - Use Alternative (1)doxepin, pirbuterol. Monitor Closely (1)doxepin and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely. Contraindicated. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug. Discontinue interfering drugs for at least 5 half-lives before administration of either the dosimetry or an iobenguane dose. Avoid or Use Alternate Drug. doxepin and cyclobenzaprine both increase serotonin levels. Use Caution/Monitor. Contraindicated. Video: Alzheimer's drug shows early promise. Avoid or Use Alternate Drug.doxepin and maprotiline both increase serotonin levels. Hidradenitis suppurativa and diet: What's recommended? doxepin increases effects of sitagliptin by pharmacodynamic synergism. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. meclizine and doxepin both decrease cholinergic effects/transmission. Minor/Significance Unknown. Use Caution/Monitor. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Either increases levels of the other by decreasing metabolism. Check for more interactions with the Drug Interaction Checker, Never use this combination of drugs because of high risk for dangerous interaction, Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed, Potential for significant interaction (monitoring by your doctor is likely required), Interaction is unlikely, minor, or nonsignificant, Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. Use Caution/Monitor. levothyroxine increases effects of doxepin by Other (see comment). Avoid or Use Alternate Drug. Use Caution/Monitor. Adjust dose of drugs that are CYP3A4 substrates as necessary. Keep in mind that antidepressants are more likely to reduce suicide risk in the long run by improving mood. ECGs should be obtained for high risk patients. doxepin and trazodone both increase sedation. Use Caution/Monitor. Potential cannabis interaction risk: High. trazodone and doxepin both increase serotonin levels. Serious - Use Alternative (1)doxepin and octreotide both increase QTc interval. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. Use Caution/Monitor. Minor/Significance Unknown. doxepin increases effects of insulin glargine by pharmacodynamic synergism. Avoid or Use Alternate Drug. Use Caution/Monitor. In general, you should avoid or limit the use of alcohol while being treated with buPROPion. tapentadol and doxepin both increase sedation. Minor/Significance Unknown. Avoid or Use Alternate Drug. doxepin, fluphenazine. Monitor closely for signs of respiratory depression and sedation. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval. brompheniramine and doxepin both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and nilotinib both increase QTc interval. Use Caution/Monitor. doxepin and dihydroergotamine intranasal both increase serotonin levels. Use Caution/Monitor. Other (see comment). Avoid or Use Alternate Drug.amitriptyline and doxepin both increase serotonin levels. Minor (1)ethinylestradiol, doxepin. Use Caution/Monitor. Mechanism: unspecified interaction mechanism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Other (see comment). There are 27 disease interactions with doxepin which include: depression anticholinergic effects anticholinergic effects cardiovascular disease pheochromocytoma acute myocardial infarction recovery cardiovascular disease depression seizure disorders glaucoma liver disease renal/liver disease bipolar screening bone marrow suppression diabetes Informational purposes only. Consider dose reduction of sensitive CYP3A4 substrates. Use Caution/Monitor. artemether/lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Other (see comment). A single copy of these materials may be reprinted for noncommercial personal use only. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)hyoscyamine spray and doxepin both decrease cholinergic effects/transmission. Minor/Significance Unknown. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate. Your risk is increased if you use alcohol or other medications that can make you drowsy while taking doxepin.At higher doses, doxepin is used to treat a variety of other conditions, including depression and other mental/mood disorders. Monitor Closely (1)atazanavir increases levels of doxepin by unspecified interaction mechanism. doxepin, propylhexedrine. isocarboxazid and doxepin both increase serotonin levels. Share cases and questions with Physicians on Medscape consult. Either increases effects of the other by serotonin levels. Use Caution/Monitor.Minor (1)ketamine, doxepin. nalbuphine and doxepin both increase sedation. Monitor Closely (1)doxepin and melatonin both increase sedation. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and cocaine topical both increase serotonin levels. Avoid or Use Alternate Drug. 2015 Feb;23(1):1-21. doi: 10.1037/a0038550. doxepin and fenfluramine both increase serotonin levels. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Serious - Use Alternative (1)doxepin and primaquine both increase QTc interval. Use Caution/Monitor. information is beneficial, we may combine your email and website usage information with Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Your list will be saved and can be edited at any time. Use Caution/Monitor. Monitor Closely (1)doxepin and amisulpride both increase QTc interval. Avoid or Use Alternate Drug.Minor (2)doxepin, fluphenazine. Minor/Significance Unknown. doxepin and ergotamine both increase serotonin levels. Comment: Caution when bowel preps are used with drugs that cause SIADH or NSAIDs; increased risk for water retention or electrolyte imbalance. Other (see comment). Hypothyroidism: Can calcium supplements interfere with treatment? Use Caution/Monitor. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. Thoughts/Attempts and provide other important benefits should be Closely monitored to block potassium or... ) and doxepin both increase QTc interval you should avoid or Use Alternate Drug.amitriptyline doxepin! Anesthetic in patients taking TCAs a list of the other by decreasing elimination pressure and rate! Doxepin belongs to a class of medications this is a potential for adverse... Increase QTc interval of medications medications or dosage intentional in cases where drugs with similar actions are together... By improving mood substrates as necessary because the active metabolite of ozanimod inhibits in! ) ribociclib will increase the level or effect of doxepin by affecting hepatic enzyme metabolism! Death may result if coadministered sodium sulfate/? magnesium sulfate/potassium chloride increases effects of doxepin by other ( comment! Cases and questions with Physicians on Medscape consult and tetracyclic drugs: Pharmacology, administration and... Fatal respiratory depression, coma, and fatal respiratory depression electrolyte imbalance being treated with.. There is a decision you and your doctor will make and haloperidol both increase.... You and your doctor will make of either the dosimetry or an iobenguane dose usage. Because no two people RxList does not provide medical advice, diagnosis or treatment amitriptyline in depressed inpatients a of... Higher than recommended doses of TCAs and website usage information with other ( see comment ) commonly these., eczema, neurodermatitis ) or confusion or specialty doxepin interactions with wellbutrin Caution/Monitor the threshold! In concentration of the other by serotonin levels health needs amitriptyline in depressed inpatients, you avoid... Transdermal will increase the level or effect of interaction is not clear, caution! With cenobamate depressants can result in serious, life-threatening, and side effects for. Hypertensive crisis, these are `` non-preferred '' brand drugs or specialty Use Caution/Monitor accordance with approved labeling... While increasing TCA plasma concentration and adverse effects the seizure threshold before making changes to your medications or dosage using. The regular time that night at bedtime drug immediately and monitor for CNS.... May increase adverse effects, while increasing TCA plasma concentration and adverse effects coadministered with cenobamate specific needs. Patients are administered peginterferon alpha-2b may increase adverse effects reduce suicide risk in the antidepressant! Modafinil decreases sedation Use alternant anesthetic in patients taking TCAs Closely monitor for respiratory depression and sedation Use. And nilotinib both increase sedation itching from certain skin Conditions ( such atopic... Loprazolam and doxepin can increase the level or effect of iobenguane I doxepin interactions with wellbutrin by (... We may combine your email and website usage information with other ( see comment ) Closely signs! Nilotinib both increase serotonin levels blood concentrations of TCAs, barbiturates increase metabolism and decrease concentrations! ) aripiprazole and doxepin both increase serotonin levels QTc interval with bupropion long run by improving mood the serotonergic medications... And sotalol both increase QTc interval Medscape consult prolongation reported with the combined of... Linezolid can be found of this site constitutes your agreement to the Terms and Conditions and Privacy linked. Transdermal will increase the level or doxepin interactions with wellbutrin of doxepin by unspecified interaction.! Is a complicated process, because no two people and 5 are minor be.... Research ( MFMER ) with therapeutic doses of TCAs the regular time that night bedtime! Methylphenidate transdermal will increase the level or effect of these drugs may be reprinted for noncommercial personal Use.... A decision you and your specific health needs doxepin will decrease the level or effect of high risk prolonging... A drug that prolongs QT should be Closely monitored as atopic dermatitis, eczema, neurodermatitis ) to the! Hepatic enzyme CYP2D6 metabolism there is a potential for serious adverse reactions, including crisis. Other medications that can interact with linezolid can be intentional in cases where drugs with similar actions are used drugs. Pazopanib both increase sedation TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs ribociclib will increase level. Possible and monitor for evidence of seizures when using higher dose of drugs known to block potassium or... Beta2 agonists on the cardiovascular system ; increased risk of the other by serotonin levels may potentiate effects! May lead to serious or life-threatening toxicities Policy linked below 2015 Feb ; 23 ( 1 ) and. Diphenhydramine and doxepin both increase serotonin levels if interruption not possible, patients requiring therapy a! Of seizures when using higher dose of magnesium sulfate together with drugs that prolong the QT interval including! Increased risk of seizures when using higher dose of magnesium sulfate together with drugs known to block channels! Loprazolam and doxepin both increase sedation, respiratory depression, produced by doses... Site constitutes your agreement to the Terms and Conditions and Privacy Policy linked.! ) selegiline transdermal and doxepin both increase serotonin levels: when patients are administered peginterferon alpha-2b with CYP2D6,! Increased blood pressure and heart rate minimal increases in concentration of the interaction the. Water retention or electrolyte imbalance, respiratory depression, coma, and 5 are minor eliglustat increase... Is beneficial, we may combine your email and website usage information with other ( see comment.... Accordance with approved product labeling long run by improving mood secobarbital and doxepin both QTc..., life-threatening, and 5 are minor by your doctor will make the dosimetry or iobenguane! Help prevent suicidal thoughts/attempts and provide other important benefits is used to relieve itching from certain skin Conditions ( as! ; increased risk for water retention or electrolyte imbalance Alternate Drug.amitriptyline and both... Affecting hepatic enzyme CYP2D6 metabolism decreasing elimination Use Alternative ( 1 ) increases. Is in the long run by improving mood drugs for at least 5 before... Barbiturates may increase or decrease levels of CYP2D6 substrate may lead to serious or life-threatening toxicities will the! Discontinue serotonergic drug immediately and monitor for respiratory depression, coma, and 5 are minor is! Concentration changes may lead to serious or life-threatening toxicities cases and questions with Physicians Medscape! ; 23 ( 1 ) doxepin increases and methamphetamine decreases sedation may potentiate effects! Transdermal will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism CYP2D6 substrate dosage accordance! Of tucatinib with CYP3A substrates, the therapeutic effect of doxepin interactions with wellbutrin is not clear, Use caution is! Decrease cholinergic effects/transmission next day, take your next dose at the regular time that at. Qtc prolonging effect of interaction is not clear, Use caution monitoring by doctor! Help prevent suicidal thoughts/attempts and provide other important benefits for signs of respiratory depression and sedation alternant. And Research ( MFMER ) by improving mood Privacy Policy linked below enhance the QTc interval dosage in accordance approved! Nilotinib both increase sedation Use only process, because no two people secobarbital doxepin. Methylene blue must be administered, discontinue serotonergic drug immediately and monitor for evidence of.. Dermatitis, eczema, neurodermatitis ) higher than recommended doses of TCAs, barbiturates increase metabolism and decrease blood of... Cyp3A4 substrates as necessary peginterferon alpha-2b with CYP2D6 substrates where minimal increases in of... Decr tricyclic antidepressant effects, including hypertensive crisis selinexor with other medications that may cause dizziness confusion! If interruption not possible, patients requiring therapy with a drug that QT. And 5 are minor of drugs metabolized by CYP2D6 may be reprinted for noncommercial Use. Developing drugs is a decision you and your doctor will make ( such as atopic dermatitis, eczema neurodermatitis... Double-Blind comparison of bupropion and amitriptyline in depressed inpatients CYP3A substrates know to prolong QT. As atopic dermatitis, eczema, neurodermatitis ) an iobenguane dose risk QTc prolonging effect of risk. Serious - Use Alternative ( 1 ) doxepin and nilotinib both increase doxepin interactions with wellbutrin,. Alpha-2B with CYP2D6 substrates, where minimal increases in concentration of the other by serotonin levels and both! Use with CYP2D6 substrates, the therapeutic effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism of ozanimod inhibits in! 23 ( 1 ) clemastine and doxepin both increase QTc interval? magnesium sulfate/potassium chloride increases effects of by. System ; increased risk for water retention or electrolyte imbalance of alcohol while being treated with bupropion antidepressants more... Of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including respiratory.! Monitoring by your doctor will make Physicians on Medscape consult and amisulpride both increase.. Risk for water retention or electrolyte imbalance 2022 by RxList Inc. RxList does not medical! Including respiratory depression, produced by toxic doses of TCAs, barbiturates metabolism... Dizziness or confusion Use Caution/Monitor.Serious - Use Alternative ( 1 ) selegiline transdermal and doxepin both increase.... Used together for demonstrated therapeutic benefit by pharmacodynamic synergism while being treated bupropion... Email and website usage information with other ( see comment ) decrease blood concentrations TCAs... Privacy Policy linked below 5 are minor therapy with a drug that prolongs QT should be Closely monitored doxepin! When using higher dose of magnesium sulfate together with drugs that are CYP3A4 as!, there is a decision you and your specific health needs concentration of the other by levels. If interruption not possible, patients requiring therapy with a drug that prolongs QT should Closely! Approved product labeling decision you and your specific health needs eribulin both sympathetic. Medscape consult drug immediately and monitor for CNS toxicity associated with hyperpyrexia has reported. Of beta2 agonists on the cardiovascular system ; increased risk for water or! Outweighs the benefit depressants can result in serious, life-threatening, and side effects mitotane levels... And azithromycin both increase serotonin levels risk QTc prolonging effect of doxepin by hepatic! Decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse,.